Double-Charge Detector 0116U

Rx mntr nzm ia 35+oral flu — 124 bundling rules

If your bill lists 0116U alongside any of these codes as separate charges, it may be an unbundling error.

By Michael Glenn , Healthcare Data Analyst · Published March 15, 2026 · Updated April 3, 2026

About the analyst

Michael Glenn reviews CMS datasets and drug pricing at BillRazor Research. He focuses on NADAC acquisition costs and procedure coding accuracy. Expertise: drug pricing, NADAC data, CPT coding.

NCCI edit data

124 code pairs

Updated 2026-04-03

Bundling rules — 0116U

NCCI edits: these codes have billing restrictions when billed with 0116U

Research suggests 49–80% of hospital bills contain errors. Our system checks every line item against Medicare benchmarks.

Common unbundling errors — medical procedures

Unbundling occurs when medical providers bill two separate codes for services that should be combined into a single charge according to National Correct Coding Initiative (NCCI) rules. In other procedures including anesthesia, radiology, pathology, and miscellaneous support services, common unbundling patterns include separately billing diagnostic imaging with its professional interpretation when both should be included in one comprehensive code, and charging for basic monitoring or preparation services alongside the primary procedure when these components are considered integral parts of the main service. Another frequent error involves billing multiple pathology examination codes for what constitutes a single comprehensive analysis. With 809 other codes subject to bundling restrictions in the NCCI database, these errors create charges above the benchmark for patients who receive multiple bills for what should constitute one complete service. The potential difference between unbundled billing and correct coding practices can significantly impact patient financial responsibility, as they may face duplicate charges for components of care that medical coding standards define as a single billable service.

What to check on your bill

When reviewing itemized bills for procedure bundling issues, patients should examine several key areas to identify potential billing irregularities. Look for multiple procedure codes billed on the same date that represent components of a comprehensive service, such as separate charges for incision, repair, and closure when these steps are typically included in one primary procedure code. Watch for code patterns where related procedures share the same first three digits, as these often indicate services that should be bundled together under Medicare's Correct Coding Initiative. Check for appropriate modifier usage, particularly modifier 59 or XS, which legitimately allow separate billing when procedures are performed on different anatomical sites or during distinct sessions. Without proper modifiers, separately billed related procedures may represent charges above the benchmark. Compare your itemized statement against standard bundling practices for your specific procedure type to identify potential differences in billing patterns.

All bundling rules for 0116U

124 code pairs that have billing restrictions with this procedure.

102

Never bill together

May bill with modifier

Code	Description	Rule
0251U	Hepcidin-25 elisa serum/plsm	May bill with modifier
80150	Assay of amikacin	Never bill together
80155	Drug assay caffeine	Never bill together
80156	Assay carbamazepine total	Never bill together
80157	Assay carbamazepine free	Never bill together
80158	Drug assay cyclosporine	Never bill together
80159	Drug assay clozapine	Never bill together
80162	Assay of digoxin total	Never bill together
80163	Assay of digoxin free	Never bill together
80164	Assay dipropylacetic acd tot	Never bill together
80165	Dipropylacetic acid free	Never bill together
80168	Assay of ethosuximide	Never bill together
80169	Drug assay everolimus	Never bill together
80170	Assay of gentamicin	Never bill together
80171	Drug screen quant gabapentin	Never bill together
80173	Assay of haloperidol	Never bill together
80175	Drug screen quan lamotrigine	Never bill together
80176	Assay of lidocaine	Never bill together
80177	Drug scrn quan levetiracetam	Never bill together
80178	Assay of lithium	Never bill together
80180	Drug scrn quan mycophenolate	Never bill together
80183	Drug scrn quant oxcarbazepin	Never bill together
80184	Assay of phenobarbital	Never bill together
80185	Assay of phenytoin total	Never bill together
80186	Assay of phenytoin free	Never bill together
80188	Assay of primidone	Never bill together
80190	Assay of procainamide	Never bill together
80192	Assay of procainamide	Never bill together
80194	Assay of quinidine	Never bill together
80195	Assay of sirolimus	Never bill together
80197	Assay of tacrolimus	Never bill together
80198	Assay of theophylline	Never bill together
80199	Drug screen quant tiagabine	Never bill together
80200	Assay of tobramycin	Never bill together
80201	Assay of topiramate	Never bill together
80202	Assay of vancomycin	Never bill together
80203	Drug screen quant zonisamide	Never bill together
80220	Drug asy hydroxychloroquine	Never bill together
80305	Drug test prsmv dir opt obs	May bill with modifier
80306	Drug test prsmv instrmnt	May bill with modifier
80320	Drug screen quantalcohols	Never bill together
80321	Alcohols biomarkers 1or 2	Never bill together
80322	Alcohols biomarkers 3/more	Never bill together
80323	Alkaloids nos	Never bill together
80324	Drug screen amphetamines 1/2	Never bill together
80325	Amphetamines 3or 4	Never bill together
80326	Amphetamines 5 or more	Never bill together
80327	Anabolic steroid 1 or 2	Never bill together
80328	Anabolic steroid 3 or more	Never bill together
80329	Analgesics non-opioid 1 or 2	Never bill together

Showing 50 of 124 rules. Show all

FAQ — medical procedure bundling

What is NCCI bundling and what does 'bundled' mean on a medical bill?

NCCI bundling refers to the National Correct Coding Initiative rules that prevent certain procedure codes from being billed separately when performed together. When codes are bundled, one procedure is considered inclusive of another, meaning only the primary procedure should be billed rather than charging for each component separately.

How can I identify if codes were incorrectly unbundled on my bill?

Incorrectly unbundled codes appear as separate line items on your bill when NCCI rules indicate they should be grouped together under one primary procedure code. This typically occurs with anesthesia, radiology, pathology, and miscellaneous support services that are considered integral to the main procedure being performed.

What should I do if I find unbundled charges on my medical bill?

Contact your healthcare provider's billing department to request a review of the charges and provide documentation showing the NCCI bundling rules that apply. Request an itemized explanation of why the codes were billed separately and ask for a corrected bill that reflects proper bundling if no valid modifier justification exists.

When is it legitimate to use modifiers to override NCCI bundling rules?

Modifiers are appropriately used when procedures are performed on different anatomical sites, during separate patient encounters, or when distinct procedural services are provided that don't fall under the bundling restrictions. The modifier usage must be supported by clear documentation in the medical record that demonstrates the services were truly separate and distinct from the bundled procedure.

Rates shown are from the 2026 Medicare Physician Fee Schedule and CMS IPPS. BillRazor compares your bill against these data sources. See how it works →

Data source: CMS National Correct Coding Initiative (NCCI) Procedure-to-Procedure (PTP) edits, updated quarterly. These code pairs are maintained by CMS to prevent improper billing of services that should be billed as a single procedure.

What this means: When two codes are listed as an NCCI edit pair, billing them separately on the same date of service is typically incorrect. "Never bill together" means no modifier can override the rule. "May bill with modifier" means the codes can be billed separately with appropriate documentation.