Double-Charge Detector 0328U

Drug assay 120+ rx&metablt — 95 bundling rules

If your bill lists 0328U alongside any of these codes as separate charges, it may be an unbundling error.

By Elena Vasquez , Medical Billing Research Lead · Published March 15, 2026 · Updated April 3, 2026

About the analyst

Elena Vasquez leads hospital billing pattern analysis at BillRazor Research. She focuses on identifying overcharges, markup outliers, and patient advocacy strategies. Expertise: hospital billing patterns, overcharge analysis, patient advocacy.

NCCI edit data

95 code pairs

Updated 2026-04-03

Bundling rules — 0328U

NCCI edits: these codes have billing restrictions when billed with 0328U

Research suggests 49–80% of hospital bills contain errors. Our system checks every line item against Medicare benchmarks.

Common unbundling errors — medical procedures

Unbundling occurs when medical providers bill two separate codes for services that should be combined into a single charge according to National Correct Coding Initiative (NCCI) rules. In other procedures including anesthesia, radiology, pathology, and miscellaneous support services, common unbundling patterns include separately billing diagnostic imaging with its professional interpretation when both should be included in one comprehensive code, and charging for basic monitoring or preparation services alongside the primary procedure when these components are considered integral parts of the main service. Another frequent error involves billing multiple pathology examination codes for what constitutes a single comprehensive analysis. With 809 other codes subject to bundling restrictions in the NCCI database, these errors create charges above the benchmark for patients who receive multiple bills for what should constitute one complete service. The potential difference between unbundled billing and correct coding practices can significantly impact patient financial responsibility, as they may face duplicate charges for components of care that medical coding standards define as a single billable service.

What to check on your bill

When reviewing itemized bills for procedure bundling issues, patients should examine several key areas to identify potential billing irregularities. Look for multiple procedure codes billed on the same date that represent components of a comprehensive service, such as separate charges for incision, repair, and closure when these steps are typically included in one primary procedure code. Watch for code patterns where related procedures share the same first three digits, as these often indicate services that should be bundled together under Medicare's Correct Coding Initiative. Check for appropriate modifier usage, particularly modifier 59 or XS, which legitimately allow separate billing when procedures are performed on different anatomical sites or during distinct sessions. Without proper modifiers, separately billed related procedures may represent charges above the benchmark. Compare your itemized statement against standard bundling practices for your specific procedure type to identify potential differences in billing patterns.

All bundling rules for 0328U

95 code pairs that have billing restrictions with this procedure.

Never bill together

May bill with modifier

Code	Description	Rule
0011U	Rx mntr lc-ms/ms oral fluid	Never bill together
0051U	Rx mntr lc-ms/ms ur/bld 31	Never bill together
0054U	Rx mntr 14+ drugs & sbsts	Never bill together
0093U	Rx mntr 65 com drugs urine	Never bill together
0110U	Rx mntr 1+oral onc rx&sbsts	Never bill together
0116U	Rx mntr nzm ia 35+oral flu	Never bill together
0119U	Crd ceramides liq chrom plsm	May bill with modifier
0251U	Hepcidin-25 elisa serum/plsm	May bill with modifier
80305	Drug test prsmv dir opt obs	Never bill together
80306	Drug test prsmv instrmnt	Never bill together
80307	Drug test prsmv chem anlyzr	Never bill together
80320	Drug screen quantalcohols	Never bill together
80321	Alcohols biomarkers 1or 2	Never bill together
80322	Alcohols biomarkers 3/more	Never bill together
80323	Alkaloids nos	Never bill together
80324	Drug screen amphetamines 1/2	Never bill together
80325	Amphetamines 3or 4	Never bill together
80326	Amphetamines 5 or more	Never bill together
80327	Anabolic steroid 1 or 2	Never bill together
80328	Anabolic steroid 3 or more	Never bill together
80329	Analgesics non-opioid 1 or 2	Never bill together
80330	Analgesics non-opioid 3-5	Never bill together
80331	Analgesics non-opioid 6/more	Never bill together
80332	Antidepressants class 1 or 2	Never bill together
80333	Antidepressants class 3-5	Never bill together
80334	Antidepressants class 6/more	Never bill together
80335	Antidepressant tricyclic 1/2	Never bill together
80336	Antidepressant tricyclic 3-5	Never bill together
80337	Tricyclic & cyclicals 6/more	Never bill together
80338	Antidepressant not specified	Never bill together
80339	Antiepileptics nos 1-3	Never bill together
80340	Antiepileptics nos 4-6	Never bill together
80341	Antiepileptics nos 7/more	Never bill together
80342	Antipsychotics nos 1-3	Never bill together
80343	Antipsychotics nos 4-6	Never bill together
80344	Antipsychotics nos 7/more	Never bill together
80345	Drug screening barbiturates	Never bill together
80346	Benzodiazepines1-12	Never bill together
80347	Benzodiazepines 13 or more	Never bill together
80348	Drug screening buprenorphine	Never bill together
80349	Cannabinoids natural	Never bill together
80350	Cannabinoids synthetic 1-3	Never bill together
80351	Cannabinoids synthetic 4-6	Never bill together
80352	Cannabinoid synthetic 7/more	Never bill together
80353	Drug screening cocaine	Never bill together
80354	Drug screening fentanyl	Never bill together
80355	Gabapentin non-blood	Never bill together
80356	Heroin metabolite	Never bill together
80357	Ketamine and norketamine	Never bill together
80358	Drug screening methadone	Never bill together

Showing 50 of 95 rules. Show all

FAQ — medical procedure bundling

What is NCCI bundling and what does 'bundled' mean on a medical bill?

NCCI bundling refers to the National Correct Coding Initiative rules that prevent certain procedure codes from being billed separately when performed together. When codes are bundled, one procedure is considered inclusive of another, meaning only the primary procedure should be billed rather than charging for each component separately.

How can I identify if codes were incorrectly unbundled on my bill?

Incorrectly unbundled codes appear as separate line items on your bill when NCCI rules indicate they should be grouped together under one primary procedure code. This typically occurs with anesthesia, radiology, pathology, and miscellaneous support services that are considered integral to the main procedure being performed.

What should I do if I find unbundled charges on my medical bill?

Contact your healthcare provider's billing department to request a review of the charges and provide documentation showing the NCCI bundling rules that apply. Request an itemized explanation of why the codes were billed separately and ask for a corrected bill that reflects proper bundling if no valid modifier justification exists.

When is it legitimate to use modifiers to override NCCI bundling rules?

Modifiers are appropriately used when procedures are performed on different anatomical sites, during separate patient encounters, or when distinct procedural services are provided that don't fall under the bundling restrictions. The modifier usage must be supported by clear documentation in the medical record that demonstrates the services were truly separate and distinct from the bundled procedure.

Rates shown are from the 2026 Medicare Physician Fee Schedule and CMS IPPS. BillRazor compares your bill against these data sources. See how it works →

Data source: CMS National Correct Coding Initiative (NCCI) Procedure-to-Procedure (PTP) edits, updated quarterly. These code pairs are maintained by CMS to prevent improper billing of services that should be billed as a single procedure.

What this means: When two codes are listed as an NCCI edit pair, billing them separately on the same date of service is typically incorrect. "Never bill together" means no modifier can override the rule. "May bill with modifier" means the codes can be billed separately with appropriate documentation.