Double-Charge Detector 0392U

Rx metab genrx ia 16 genes — 380 bundling rules

If your bill lists 0392U alongside any of these codes as separate charges, it may be an unbundling error.

By Michael Glenn , Healthcare Data Analyst · Published March 15, 2026 · Updated April 3, 2026

About the analyst

Michael Glenn reviews CMS datasets and drug pricing at BillRazor Research. He focuses on NADAC acquisition costs and procedure coding accuracy. Expertise: drug pricing, NADAC data, CPT coding.

NCCI edit data

380 code pairs

Updated 2026-04-03

Bundling rules — 0392U

NCCI edits: these codes have billing restrictions when billed with 0392U

Research suggests 49–80% of hospital bills contain errors. Our system checks every line item against Medicare benchmarks.

Common unbundling errors — medical procedures

Unbundling occurs when medical providers bill two separate codes for services that should be combined into a single charge according to National Correct Coding Initiative (NCCI) rules. In other procedures including anesthesia, radiology, pathology, and miscellaneous support services, common unbundling patterns include separately billing diagnostic imaging with its professional interpretation when both should be included in one comprehensive code, and charging for basic monitoring or preparation services alongside the primary procedure when these components are considered integral parts of the main service. Another frequent error involves billing multiple pathology examination codes for what constitutes a single comprehensive analysis. With 809 other codes subject to bundling restrictions in the NCCI database, these errors create charges above the benchmark for patients who receive multiple bills for what should constitute one complete service. The potential difference between unbundled billing and correct coding practices can significantly impact patient financial responsibility, as they may face duplicate charges for components of care that medical coding standards define as a single billable service.

What to check on your bill

When reviewing itemized bills for procedure bundling issues, patients should examine several key areas to identify potential billing irregularities. Look for multiple procedure codes billed on the same date that represent components of a comprehensive service, such as separate charges for incision, repair, and closure when these steps are typically included in one primary procedure code. Watch for code patterns where related procedures share the same first three digits, as these often indicate services that should be bundled together under Medicare's Correct Coding Initiative. Check for appropriate modifier usage, particularly modifier 59 or XS, which legitimately allow separate billing when procedures are performed on different anatomical sites or during distinct sessions. Without proper modifiers, separately billed related procedures may represent charges above the benchmark. Compare your itemized statement against standard bundling practices for your specific procedure type to identify potential differences in billing patterns.

All bundling rules for 0392U

380 code pairs that have billing restrictions with this procedure.

Never bill together

367

May bill with modifier

Code	Description	Rule
0009U	Onc brst ca erbb2 amp/nonamp	May bill with modifier
0016U	Onc hmtlmf neo rna bcr/abl1	May bill with modifier
0017U	Onc hmtlmf neo jak2 mut dna	May bill with modifier
0027U	Jak2 gene trgt seq alys	May bill with modifier
0029U	Rx metab advrs trgt seq alys	May bill with modifier
0030U	Rx metab warf trgt seq alys	May bill with modifier
0034U	Tpmt nudt15 genes	May bill with modifier
0040U	Bcr/abl1 gene major bp quan	May bill with modifier
0046U	Flt3 gene itd variants quan	May bill with modifier
0049U	Npm1 gene analysis quan	May bill with modifier
0069U	Onc clrct microrna mir-31-3p	May bill with modifier
0070U	Cyp2d6 gen com&slct rar vrnt	May bill with modifier
0071U	Cyp2d6 full gene sequence	Never bill together
0072U	Cyp2d6 gen cyp2d6-2d7 hybrid	Never bill together
0073U	Cyp2d6 gen cyp2d7-2d6 hybrid	Never bill together
0074U	Cyp2d6 nonduplicated gene	Never bill together
0075U	Cyp2d6 5' gene dup/mlt	Never bill together
0076U	Cyp2d6 3' gene dup/mlt	Never bill together
0086U	Nfct ds bact&fng org id 6+	May bill with modifier
0111U	Onc colon ca kras&nras alys	May bill with modifier
0112U	Iadi 16s&18s rrna genes	May bill with modifier
0115U	Respir iadna 18 viral&2 bact	May bill with modifier
0136U	Atm mrna seq alys	May bill with modifier
0137U	Palb2 mrna seq alys	May bill with modifier
0138U	Brca1 brca2 mrna seq alys	May bill with modifier
0140U	Nfct ds fungi dna 15 trgt	May bill with modifier
0141U	Nfct ds bact&fng gram pos	May bill with modifier
0142U	Nfct ds bact&fng gram neg	May bill with modifier
0155U	Onc brst ca dna pik3ca gene	May bill with modifier
0156U	Copy number sequence alys	May bill with modifier
0157U	Apc mrna seq alys	May bill with modifier
0158U	Mlh1 mrna seq alys	May bill with modifier
0159U	Msh2 mrna seq alys	May bill with modifier
0160U	Msh6 mrna seq alys	May bill with modifier
0161U	Pms2 mrna seq alys	May bill with modifier
0169U	Nudt15&tpmt gene com vrnt	May bill with modifier
0177U	Onc brst ca dna pik3ca 11	May bill with modifier
0202U	Nfct ds 22 trgt sars-cov-2	May bill with modifier
0229U	Bcat1&ikzf1 prmtr mthyln aly	May bill with modifier
0230U	Ar full sequence analysis	May bill with modifier
0231U	Cacna1a full gene analysis	May bill with modifier
0233U	Fxn gene analysis	May bill with modifier
0234U	Mecp2 full gene analysis	May bill with modifier
0235U	Pten full gene analysis	May bill with modifier
0236U	Smn1&smn2 full gene analysis	May bill with modifier
0252U	Ftl aneuploidy str alys dna	May bill with modifier
0476U	Rx metab psyc 14gen&cyp2d6	Never bill together
0477U	Rx metab psy 14&cyp2d6 gn-rx	Never bill together
0500U	Autoinflam ds vexas synd dna	May bill with modifier
0516U	Rx metab rxgenomic gnotyp 40	Never bill together

Showing 50 of 380 rules. Show all

FAQ — medical procedure bundling

What is NCCI bundling and what does 'bundled' mean on a medical bill?

NCCI bundling refers to the National Correct Coding Initiative rules that prevent certain procedure codes from being billed separately when performed together. When codes are bundled, one procedure is considered inclusive of another, meaning only the primary procedure should be billed rather than charging for each component separately.

How can I identify if codes were incorrectly unbundled on my bill?

Incorrectly unbundled codes appear as separate line items on your bill when NCCI rules indicate they should be grouped together under one primary procedure code. This typically occurs with anesthesia, radiology, pathology, and miscellaneous support services that are considered integral to the main procedure being performed.

What should I do if I find unbundled charges on my medical bill?

Contact your healthcare provider's billing department to request a review of the charges and provide documentation showing the NCCI bundling rules that apply. Request an itemized explanation of why the codes were billed separately and ask for a corrected bill that reflects proper bundling if no valid modifier justification exists.

When is it legitimate to use modifiers to override NCCI bundling rules?

Modifiers are appropriately used when procedures are performed on different anatomical sites, during separate patient encounters, or when distinct procedural services are provided that don't fall under the bundling restrictions. The modifier usage must be supported by clear documentation in the medical record that demonstrates the services were truly separate and distinct from the bundled procedure.

Rates shown are from the 2026 Medicare Physician Fee Schedule and CMS IPPS. BillRazor compares your bill against these data sources. See how it works →

Data source: CMS National Correct Coding Initiative (NCCI) Procedure-to-Procedure (PTP) edits, updated quarterly. These code pairs are maintained by CMS to prevent improper billing of services that should be billed as a single procedure.

What this means: When two codes are listed as an NCCI edit pair, billing them separately on the same date of service is typically incorrect. "Never bill together" means no modifier can override the rule. "May bill with modifier" means the codes can be billed separately with appropriate documentation.