Onc pan solid tum alys dna — 156 bundling rules
If your bill lists 0422U alongside any of these codes as separate charges, it may be an unbundling error.
About the analyst
Priya Iyengar leads the billing code review team at BillRazor Research. She analyzes NCCI bundling edits, DRG coding, and regional rate variation. Expertise: NCCI bundling, DRG analysis, regional pricing.
Common unbundling errors — medical procedures
Unbundling occurs when medical providers bill two separate codes for services that should be combined into a single charge according to National Correct Coding Initiative (NCCI) rules. In other procedures including anesthesia, radiology, pathology, and miscellaneous support services, common unbundling patterns include separately billing diagnostic imaging with its professional interpretation when both should be included in one comprehensive code, and charging for basic monitoring or preparation services alongside the primary procedure when these components are considered integral parts of the main service. Another frequent error involves billing multiple pathology examination codes for what constitutes a single comprehensive analysis. With 809 other codes subject to bundling restrictions in the NCCI database, these errors create charges above the benchmark for patients who receive multiple bills for what should constitute one complete service. The potential difference between unbundled billing and correct coding practices can significantly impact patient financial responsibility, as they may face duplicate charges for components of care that medical coding standards define as a single billable service.
What to check on your bill
When reviewing itemized bills for procedure bundling issues, patients should examine several key areas to identify potential billing irregularities. Look for multiple procedure codes billed on the same date that represent components of a comprehensive service, such as separate charges for incision, repair, and closure when these steps are typically included in one primary procedure code. Watch for code patterns where related procedures share the same first three digits, as these often indicate services that should be bundled together under Medicare's Correct Coding Initiative. Check for appropriate modifier usage, particularly modifier 59 or XS, which legitimately allow separate billing when procedures are performed on different anatomical sites or during distinct sessions. Without proper modifiers, separately billed related procedures may represent charges above the benchmark. Compare your itemized statement against standard bundling practices for your specific procedure type to identify potential differences in billing patterns.
All bundling rules for 0422U
156 code pairs that have billing restrictions with this procedure.
| Code | Description | Rule |
|---|---|---|
| 0220U | Onc brst ca ai assmt 12 feat | May bill with modifier |
| 0242U | Trgt gen seq alys pnl 55-74 | Never bill together |
| 0248U | Onc sphrd cell cul 12 rx pnl | May bill with modifier |
| 0326U | Trgt gen seq alys pnl 83+ | May bill with modifier |
| 0334U | Onc sld orgn tgsa dna 84/+ | May bill with modifier |
| 36591 | Draw blood off venous device | Never bill together |
| 36592 | Collect blood from picc | Never bill together |
| 80503 | Path clin consltj sf 5-20 | May bill with modifier |
| 80504 | Path clin consltj mod 21-40 | May bill with modifier |
| 80505 | Path clin consltj high 41-60 | May bill with modifier |
| 81105 | Hpa-1 genotyping | May bill with modifier |
| 81106 | Hpa-2 genotyping | May bill with modifier |
| 81107 | Hpa-3 genotyping | May bill with modifier |
| 81108 | Hpa-4 genotyping | May bill with modifier |
| 81109 | Hpa-5 genotyping | May bill with modifier |
| 81110 | Hpa-6 genotyping | May bill with modifier |
| 81111 | Hpa-9 genotyping | May bill with modifier |
| 81112 | Hpa-15 genotyping | May bill with modifier |
| 81120 | Idh1 common variants | May bill with modifier |
| 81121 | Idh2 common variants | May bill with modifier |
| 81162 | Brca1&2 gen full seq dup/del | May bill with modifier |
| 81163 | Brca1&2 gene full seq alys | May bill with modifier |
| 81164 | Brca1&2 gen ful dup/del alys | May bill with modifier |
| 81165 | Brca1 gene full seq alys | May bill with modifier |
| 81166 | Brca1 gene full dup/del alys | May bill with modifier |
| 81167 | Brca2 gene full dup/del alys | May bill with modifier |
| 81168 | Ccnd1/igh translocation alys | May bill with modifier |
| 81170 | Abl1 gene | May bill with modifier |
| 81175 | Asxl1 full gene sequence | May bill with modifier |
| 81176 | Asxl1 gene target seq alys | May bill with modifier |
| 81191 | Ntrk1 translocation analysis | May bill with modifier |
| 81192 | Ntrk2 translocation analysis | May bill with modifier |
| 81193 | Ntrk3 translocation analysis | May bill with modifier |
| 81194 | Ntrk translocation analysis | May bill with modifier |
| 81201 | Apc gene full sequence | May bill with modifier |
| 81202 | Apc gene known fam variants | May bill with modifier |
| 81203 | Apc gene dup/delet variants | May bill with modifier |
| 81206 | Bcr/abl1 gene major bp | May bill with modifier |
| 81207 | Bcr/abl1 gene minor bp | May bill with modifier |
| 81208 | Bcr/abl1 gene other bp | May bill with modifier |
| 81210 | Braf gene | May bill with modifier |
| 81212 | Brca1&2 185&5385&6174 vrnt | May bill with modifier |
| 81215 | Brca1 gene known famil vrnt | May bill with modifier |
| 81216 | Brca2 gene full seq alys | May bill with modifier |
| 81217 | Brca2 gene known famil vrnt | May bill with modifier |
| 81218 | Cebpa gene full sequence | May bill with modifier |
| 81219 | Calr gene com variants | May bill with modifier |
| 81225 | Cyp2c19 gene com variants | May bill with modifier |
| 81226 | Cyp2d6 gene com variants | May bill with modifier |
| 81227 | Cyp2c9 gene com variants | May bill with modifier |
Showing 50 of 156 rules. Show all
FAQ — medical procedure bundling
What is NCCI bundling and what does 'bundled' mean on a medical bill?
How can I identify if codes were incorrectly unbundled on my bill?
What should I do if I find unbundled charges on my medical bill?
When is it legitimate to use modifiers to override NCCI bundling rules?
Data source: CMS National Correct Coding Initiative (NCCI) Procedure-to-Procedure (PTP) edits, updated quarterly. These code pairs are maintained by CMS to prevent improper billing of services that should be billed as a single procedure.
What this means: When two codes are listed as an NCCI edit pair, billing them separately on the same date of service is typically incorrect. "Never bill together" means no modifier can override the rule. "May bill with modifier" means the codes can be billed separately with appropriate documentation.