Double-Charge Detector 0425U

Genom rpd seq alys ea cmprtr — 394 bundling rules

If your bill lists 0425U alongside any of these codes as separate charges, it may be an unbundling error.

By Michael Glenn , Healthcare Data Analyst · Published March 15, 2026 · Updated April 3, 2026

About the analyst

Michael Glenn reviews CMS datasets and drug pricing at BillRazor Research. He focuses on NADAC acquisition costs and procedure coding accuracy. Expertise: drug pricing, NADAC data, CPT coding.

NCCI edit data

394 code pairs

Updated 2026-04-03

Bundling rules — 0425U

NCCI edits: these codes have billing restrictions when billed with 0425U

Research suggests 49–80% of hospital bills contain errors. Our system checks every line item against Medicare benchmarks.

Common unbundling errors — medical procedures

Unbundling occurs when medical providers bill two separate codes for services that should be combined into a single charge according to National Correct Coding Initiative (NCCI) rules. In other procedures including anesthesia, radiology, pathology, and miscellaneous support services, common unbundling patterns include separately billing diagnostic imaging with its professional interpretation when both should be included in one comprehensive code, and charging for basic monitoring or preparation services alongside the primary procedure when these components are considered integral parts of the main service. Another frequent error involves billing multiple pathology examination codes for what constitutes a single comprehensive analysis. With 809 other codes subject to bundling restrictions in the NCCI database, these errors create charges above the benchmark for patients who receive multiple bills for what should constitute one complete service. The potential difference between unbundled billing and correct coding practices can significantly impact patient financial responsibility, as they may face duplicate charges for components of care that medical coding standards define as a single billable service.

What to check on your bill

When reviewing itemized bills for procedure bundling issues, patients should examine several key areas to identify potential billing irregularities. Look for multiple procedure codes billed on the same date that represent components of a comprehensive service, such as separate charges for incision, repair, and closure when these steps are typically included in one primary procedure code. Watch for code patterns where related procedures share the same first three digits, as these often indicate services that should be bundled together under Medicare's Correct Coding Initiative. Check for appropriate modifier usage, particularly modifier 59 or XS, which legitimately allow separate billing when procedures are performed on different anatomical sites or during distinct sessions. Without proper modifiers, separately billed related procedures may represent charges above the benchmark. Compare your itemized statement against standard bundling practices for your specific procedure type to identify potential differences in billing patterns.

All bundling rules for 0425U

394 code pairs that have billing restrictions with this procedure.

Never bill together

391

May bill with modifier

Code	Description	Rule
0001U	Rbc dna hea 35 ag 11 bld grp	May bill with modifier
0004M	Scoliosis dna alys	May bill with modifier
0005U	Onco prst8 3 gene ur alg	May bill with modifier
0006M	Onc hep gene risk classifier	May bill with modifier
0007M	Onc gastro 51 gene nomogram	May bill with modifier
0008U	Hpylori detcj abx rstnc dna	May bill with modifier
0009U	Onc brst ca erbb2 amp/nonamp	May bill with modifier
0011M	Onc prst8 ca mrna 12 gen alg	May bill with modifier
0012M	Onc mrna 5 gen rsk urthl ca	May bill with modifier
0013M	Onc mrna 5 gen recr urthl ca	May bill with modifier
0016M	Onc bladder mrna 219 gen alg	May bill with modifier
0016U	Onc hmtlmf neo rna bcr/abl1	May bill with modifier
0017U	Onc hmtlmf neo jak2 mut dna	May bill with modifier
0018U	Onc thyr 10 microrna seq alg	May bill with modifier
0023U	Onc aml dna detcj/nondetcj	May bill with modifier
0026U	Onc thyr dna&mrna 112 genes	May bill with modifier
0027U	Jak2 gene trgt seq alys	May bill with modifier
0029U	Rx metab advrs trgt seq alys	May bill with modifier
0030U	Rx metab warf trgt seq alys	May bill with modifier
0034U	Tpmt nudt15 genes	May bill with modifier
0040U	Bcr/abl1 gene major bp quan	May bill with modifier
0045U	Onc brst dux carc is 12 gene	May bill with modifier
0046U	Flt3 gene itd variants quan	May bill with modifier
0047U	Onc prst8 mrna 17 gene alg	May bill with modifier
0048U	Onc sld org neo dna 468 gene	May bill with modifier
0049U	Npm1 gene analysis quan	May bill with modifier
0050U	Trgt gen seq dna 194 genes	May bill with modifier
0055U	Card hrt trnspl 96 dna seq	May bill with modifier
0060U	Twn zyg gen seq alys chrms2	May bill with modifier
0069U	Onc clrct microrna mir-31-3p	May bill with modifier
0070U	Cyp2d6 gen com&slct rar vrnt	May bill with modifier
0084U	Rbc dna gnotyp 10 bld groups	May bill with modifier
0087U	Crd hrt trnspl mrna 1283 gen	May bill with modifier
0088U	Trnsplj kdn algrft rej 1494	May bill with modifier
0089U	Onc mlnma prame & linc00518	May bill with modifier
0090U	Onc cutan mlnma mrna 23 gene	May bill with modifier
0108U	Gi barrett esoph 9 prtn bmrk	May bill with modifier
0111U	Onc colon ca kras&nras alys	May bill with modifier
0113U	Onc prst8 pca3&tmprss2-erg	May bill with modifier
0118U	Trnsplj don-drv cll-fr dna	May bill with modifier
0120U	Onc b cll lymphm mrna 58 gen	May bill with modifier
0129U	Hered brst ca rltd do panel	May bill with modifier
0155U	Onc brst ca dna pik3ca gene	May bill with modifier
0156U	Copy number sequence alys	May bill with modifier
0169U	Nudt15&tpmt gene com vrnt	May bill with modifier
0170U	Neuro asd rna next gen seq	May bill with modifier
0177U	Onc brst ca dna pik3ca 11	May bill with modifier
0228U	Onc prst8 ma molec prfl alg	May bill with modifier
0229U	Bcat1&ikzf1 prmtr mthyln aly	May bill with modifier
0230U	Ar full sequence analysis	May bill with modifier

Showing 50 of 394 rules. Show all

FAQ — medical procedure bundling

What is NCCI bundling and what does 'bundled' mean on a medical bill?

NCCI bundling refers to the National Correct Coding Initiative rules that prevent certain procedure codes from being billed separately when performed together. When codes are bundled, one procedure is considered inclusive of another, meaning only the primary procedure should be billed rather than charging for each component separately.

How can I identify if codes were incorrectly unbundled on my bill?

Incorrectly unbundled codes appear as separate line items on your bill when NCCI rules indicate they should be grouped together under one primary procedure code. This typically occurs with anesthesia, radiology, pathology, and miscellaneous support services that are considered integral to the main procedure being performed.

What should I do if I find unbundled charges on my medical bill?

Contact your healthcare provider's billing department to request a review of the charges and provide documentation showing the NCCI bundling rules that apply. Request an itemized explanation of why the codes were billed separately and ask for a corrected bill that reflects proper bundling if no valid modifier justification exists.

When is it legitimate to use modifiers to override NCCI bundling rules?

Modifiers are appropriately used when procedures are performed on different anatomical sites, during separate patient encounters, or when distinct procedural services are provided that don't fall under the bundling restrictions. The modifier usage must be supported by clear documentation in the medical record that demonstrates the services were truly separate and distinct from the bundled procedure.

Rates shown are from the 2026 Medicare Physician Fee Schedule and CMS IPPS. BillRazor compares your bill against these data sources. See how it works →

Data source: CMS National Correct Coding Initiative (NCCI) Procedure-to-Procedure (PTP) edits, updated quarterly. These code pairs are maintained by CMS to prevent improper billing of services that should be billed as a single procedure.

What this means: When two codes are listed as an NCCI edit pair, billing them separately on the same date of service is typically incorrect. "Never bill together" means no modifier can override the rule. "May bill with modifier" means the codes can be billed separately with appropriate documentation.