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Generic J3420 · Vitamins & Supplements

CYANOCOBALAMIN 1,000 MCG/ML VL

CYANOCOBALAMIN 1,000 MCG/ML VL, a generic vitamin B12 supplement, has a NADAC acquisition cost of $1.85, though hospitals typically charge 10-50 times this amount for the same medication.

By Michael Glenn , Healthcare Data Analyst · ·
Data from CMS files published FY 2024 CMS IPPS. Refreshed weekly.
About the analyst

Michael Glenn reviews CMS datasets and drug pricing at BillRazor Research. He focuses on NADAC acquisition costs and procedure coding accuracy. Expertise: drug pricing, NADAC data, CPT coding.

NADAC acquisition cost data
CMS drug pricing benchmarks
Updated 2026-04-03
Drug acquisition cost — CYANOCOBALAMIN 1,000 MCG/ML VL
NADAC cost$1.85 per unit
Hospital charges for this drug vary — typically 3–8x the acquisition cost. No observed hospital charge data is available for this specific drug.
$1.85
NADAC acquisition cost
INJECTABLE
Dosage form
INJECTION
Route

Cyanocobalamin is a synthetic form of vitamin B12 used to treat deficiency conditions, commonly administered via injection. This generic medication typically has lower reimbursement rates compared to brand-name B12 formulations, with Medicare coverage varying based on documented deficiency diagnosis codes.

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Research suggests 49–80% of hospital bills contain errors. Our system checks every line item against Medicare benchmarks.

What to check on your bill

When reviewing vitamin and supplement charges on your hospital bill, examine line items for specific product names rather than generic descriptions like "nutritional support" or "dietary supplement." Look for charges above the benchmark for common items such as vitamin D tablets, multivitamins, calcium supplements, or protein powders that typically cost under $20 retail but may appear as $50-200 hospital charges. Check for duplicate entries where the same supplement appears multiple times on different days without clear medical justification. Verify that specialized therapeutic vitamins like prescription-strength B12 injections or IV vitamin formulations are appropriately distinguished from over-the-counter equivalents on your bill. Compare itemized supplement charges against your medication administration records to confirm you actually received each product listed. Pay attention to quantity discrepancies where single doses are billed as full bottles or where standard oral vitamins are coded as specialized formulations, creating potential differences of $30-150 per item.

Rates shown are from the 2026 Medicare Physician Fee Schedule and CMS IPPS. BillRazor compares your bill against these data sources. See how it works →

FAQ — Vitamins & Supplements billing

What is the average acquisition cost for vitamins and supplements in drug billing?
The average NADAC acquisition cost for vitamins and supplements is $3.77 across 12 drugs in this therapeutic class. This benchmark represents the national average drug acquisition cost used for billing reference purposes.
How many prescription drugs are included in the vitamins and supplements billing category?
There are 12 prescription drugs classified under vitamins and supplements for billing purposes. This category encompasses various prescription-grade vitamin and nutritional supplement formulations that require proper coding and billing procedures.
What should I know about billing discrepancies for vitamins and supplements?
Claims showing charges above the benchmark of $3.77 may indicate potential billing review opportunities within this drug class. The potential difference between billed amounts and the NADAC benchmark can vary significantly depending on the specific vitamin or supplement prescribed.
Are over-the-counter vitamins included in prescription drug billing data?
Only prescription vitamins and supplements that require a doctor's prescription are included in this billing data and the $3.77 average cost figure. Over-the-counter vitamins are not part of prescription drug billing systems and would not appear in NADAC pricing data.

Related pricing data

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Data source: National Average Drug Acquisition Cost (NADAC) survey, published by CMS. HCPCS drug pricing codes from Medicare Part B Drug Average Sales Price file.

What NADAC means: The average price pharmacies pay to acquire this drug from wholesalers. Hospital charges for the same drug are typically higher due to facility fees, compounding, and administration costs.

Limitations: NADAC reflects pharmacy acquisition cost, not patient out-of-pocket cost. Insurance copays, formulary tiers, and manufacturer rebates affect what patients actually pay.

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