Generic

DESONIDE 0.05% CREAM

DESONIDE 0.05% CREAM, a generic topical corticosteroid with an acquisition cost of $0.23, often shows significant price variations between acquisition cost and hospital billing rates.

By Kevin Nyk , Medical Billing Analyst · Published March 15, 2026 · Updated April 3, 2026

Data from CMS files published FY 2024 CMS IPPS. Refreshed weekly.

About the analyst

Kevin Nyk analyzes hospital pricing data at BillRazor Research. He specializes in Medicare reimbursement patterns and chargemaster pricing across U.S. hospitals. Expertise: hospital pricing, Medicare rates, chargemaster analysis.

NADAC acquisition cost data

CMS drug pricing benchmarks

Updated 2026-04-03

Drug acquisition cost — DESONIDE 0.05% CREAM

Hospital charges for this drug vary — typically 3–8x the acquisition cost. No observed hospital charge data is available for this specific drug.

$0.23

NADAC acquisition cost

OINTMENT

Dosage form

TOPICAL

Route

Desonide 0.05% cream is a topical corticosteroid prescribed for inflammatory skin conditions like eczema and dermatitis. This generic formulation typically generates lower reimbursement rates compared to brand-name alternatives, with Medicare coverage varying based on prior authorization requirements.

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Data source: National Average Drug Acquisition Cost (NADAC) survey, published by CMS. HCPCS drug pricing codes from Medicare Part B Drug Average Sales Price file.

What NADAC means: The average price pharmacies pay to acquire this drug from wholesalers. Hospital charges for the same drug are typically higher due to facility fees, compounding, and administration costs.

Limitations: NADAC reflects pharmacy acquisition cost, not patient out-of-pocket cost. Insurance copays, formulary tiers, and manufacturer rebates affect what patients actually pay.