Generic J2550

PROMETHAZINE 25 MG/ML AMPUL

PROMETHAZINE 25 MG/ML AMPUL, a generic medication with an acquisition cost of $1.36, often shows significant pricing variation between acquisition and hospital billing rates.

By Priya Iyengar , Senior Billing Analyst · Published March 15, 2026 · Updated April 3, 2026

Data from CMS files published FY 2024 CMS IPPS. Refreshed weekly.

About the analyst

Priya Iyengar leads the billing code review team at BillRazor Research. She analyzes NCCI bundling edits, DRG coding, and regional rate variation. Expertise: NCCI bundling, DRG analysis, regional pricing.

NADAC acquisition cost data

CMS drug pricing benchmarks

Updated 2026-04-03

Drug acquisition cost — PROMETHAZINE 25 MG/ML AMPUL

Hospital charges for this drug vary — typically 3–8x the acquisition cost. No observed hospital charge data is available for this specific drug.

$1.36

NADAC acquisition cost

INJECTABLE

Dosage form

INJECTION

Route

Promethazine is an antihistamine used for allergies, nausea, and sedation, commonly administered via injection in hospital settings. This generic medication typically shows significant price variation between facilities, with charges often exceeding Medicare reimbursement rates by substantial multiples.

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Data source: National Average Drug Acquisition Cost (NADAC) survey, published by CMS. HCPCS drug pricing codes from Medicare Part B Drug Average Sales Price file.

What NADAC means: The average price pharmacies pay to acquire this drug from wholesalers. Hospital charges for the same drug are typically higher due to facility fees, compounding, and administration costs.

Limitations: NADAC reflects pharmacy acquisition cost, not patient out-of-pocket cost. Insurance copays, formulary tiers, and manufacturer rebates affect what patients actually pay.